contrast-induced nephropathy
Conditions
Interventions
salvianolate group:Intravenous salvianolate (400mg+0.9% normal saline 500ml, a rate of 100ml/h) during the procedure, followed by continues infusion (400mg+0.9% normal saline 250ml, a rate of 100ml/h)
narmal saline hydration group:Intravenous hydration with normal saline at a rate of 1ml/kg/h during the procedure and lasting for 12h after primary PCI
Sponsors
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
25 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients who were diagnosed with STEMI, NSTEMI or high-risk ACS underwent emergency coronary angiography and primary PCI; 2. Patients met the indication for emergency coronary angiography and primary PCI.
Exclusion criteria
Exclusion criteria: 1. In a critical condition or other conditions which might seriously impact treatment outcomes and prognosis on admission, such as cardiogenic shock, congestive heart failure (New York Heart Association class IV), severe renal or hepatic insufficiency (e.g. cirrhosis, pre-existing end-stage renal disease requiring dialysis), active gastrointestinal bleeding, acute stroke and terminal malignancies; 2. Being considered not suitable for procedure by operation group, such as contraindication to antiplatelet therapy, mental disorder, fever of undetermined origin (>38.5 degree C), uncontrolled infection and severe wasting; 3. Allergic to contrast agent or salvianolate; 4. Pregnancy or lactation; 5. Other conditions determined by researchers should be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum creatinine;eGFR;Cys C;the incedence of CIN; | — |
Countries
China
Contacts
Public ContactLu Zhigang
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University
Outcome results
None listed