Clinical Research of Dexmeditomidine Administration in elderly Orthopedic Surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-16009829

Enrollment

Unknown

Registered

2016-11-11

Start date

2016-12-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depth of Anesthesia/ Postoperative Cognitive dysfunvtion

Interventions

Part I (Cohort study design): Elder group

Young people Group:Dexmeditomidine iv.

Part Two (RCT design): Group A, B, C:A: Dexmeditomidine

B: propfol

C: normal saline

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Part I (Cohort study design): 1. The patients agreed to take part in the study and signed informed consent; 2. ASA grading I-II; 3. Aged 18 to 80 years; 4. Undergiong elective unilateral total knee replacement (TKA) because of knee osteoarthritis. Part II (Randomized controlled trial design): 1. ASA grading I-II; 2. Aged 65 to 80 years; 3. Undergiong elective unilateral total knee replacement (TKA) because of knee osteoarthritis.

Exclusion criteria

Exclusion criteria: Part I: 1. Not suitable for nerve block (infection on puncture sites, coagulopathy disorders, allergy to local anesthetics, neurological diseases, motor or sensory disturbance); 2. Allergy to a2 adrenergic receptor agonist; 3. Psychiatric history, Parkinson's disease, hearing disorder; 4. Refuse to nerve block anesthesia with or without sedation. Part II: 1. Not suitable for nerve block (infection on puncture sites, coagulopathy disorders, allergy to local anesthetics, neurological diseases, motor or sensory disturbance); 2. Allergy to a2 adrenergic receptor agonist, propofol; 3. Psychiatric history, Parkinson's disease, hearing disorder; 4. Refuse to nerve block anesthesia with or without sedation; 5. Preoperative mini-mental state examination (MMSE) score <25; 6. Underwent operation within 1 year.

Design outcomes

Primary

Measure	Time frame
OAA/S score;Bispectral Index;Postoperative Cognitive Dysfunction Scale;Serum C-reactive protein;Serum Interleukin-6;Serum Adrenocorticotropic Hormone;Serum Cortisol;Delium CAM Scale;	—

Secondary

Measure	Time frame
Blood Pressure;Heart Rate;visual analogue pain scale;Beck Depression Inventory;Iowa anesthesia satisfaction scale;	—

Countries

China

Contacts

Public ContactChen Wang

Chinese PLA General Hospital

15210146136@163.com+86 15210146136

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026