osteoarthritis,OA
Conditions
Interventions
Synchronization group:Judging by the researcher
Sequential group:Judging by the researcher
Sponsors
Ningbo First Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40-75 years old male or female; 2. In accordance with knee osteoarthritis (OA) diagnostic criteria; 3. X-ray Kellgren - Lawrence class for 1-3 (on both sides of the joints involved aiming at more serious side joints); 4. WOMAC (Likert type) pain score more than 6 cent; 5. The efficacy of non-drug therapy and simple poor analgesic; 6. Voluntary and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) The knee pain of other inflammatory diseases, such as rheumatoid arthritis, psoriatic arthritis, gout, tumor, villonodular synovitis, joint trauma, suppurative arthritis, tuberculosis arthritis; (2) The serious gastrointestinal diseases, such as gastrointestinal ulcers, gastrointestinal bleeding, ulcerative colitis, Crohn's syndrome, acute pancreatitis, etc; (3) Serious cardiovascular, cerebrovascular, blood system, liver, kidney diseases, diabetic patients; (4) Mental illness or mental retardation can not correctly describe their own feelings; (5) Systemic infection or patients with infectious diseases treatment period; (6) Screening conducted joint cavity within three months before treatment, including joint cavity medicine injection and articular cavity cleaning and arthroscopic surgery, etc. (7) To participate in other clinical trials of similar drugs in the first 3 months; (8) The drug is being treated for osteoarthritis and the drug has a half-life of more than 35 hours; (9) In the first 6 months, the site has trauma or surgery, or the site has 3 or more trauma or surgical history; (10) Knee osteoarthritis, joint space narrow obviously, patients with operation indications; (11) Knee joint anatomical abnormalities of patients; (12) On research with drugs (amino glucose, sodium hyaluronate) and similar drug allergies; (13) Pregnant women, nursing mothers, or perhaps the pregnancy women; (14) Unable or unwilling to provide informed consent or poor compliance of patients; (15) Researchers think that should not be in the study of other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities;Lequesne; | — |
Countries
China
Contacts
Public ContactJia Xuewen
Ningbo First Hospital
Outcome results
None listed