Acute leukemia, Myelodysplastic syndrome, chronic myeloid leukemia, malignant lymphoma
Conditions
Interventions
single cord blood transplantation:Total-body radiotherapy-predominant conditioning regimens
Sponsors
Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
2 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Aged 2-50 years old; 2. According to NCCN guidline, All patients with hematologic malignancies eligible for allogeneic hematopoietic stem cell transplantation and lack of a suitable unrelated donor; 3. ECOG<2; 4. Free and informed consent signed by the patient and the investigator.
Exclusion criteria
Exclusion criteria: 1. Malignant myeloid or lymphoid acute or chronic disease without indication for an allogeneic transplant according to the criteria of European Bone Marrow Transplantation Group; 2. HLA-identical sibling available; 3. Availability of an unrelated donor on a national or international register with 10/10 or 9/10 HLA matching (HLA-C Mismatch tolerated); 4. Women of childbearing age not using contraception, pregnant or lactating; 5. History of allogeneic stem cell transplantation; 6. History of a total body irradiation; 7. Organ failure or patient general status considered to be incompatible with a myeloablative conditioning regimen; 8. Active psychiatric disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Count of blood cells;Subsets of T cells;Subsets of B cells;cytokines;Detection of Engraftment Evidence;morphology of bone marrow cell;function of live and kidney;Dectation of minimal residual disease;detection of EB virus;detection of CMV virus; | — |
Contacts
Public ContactHAO SI GUO
Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicne
Outcome results
None listed