Early post-operative hyperbilirubinemia after liver transplantation
Conditions
Interventions
Trial group:Methylprednisolone 1mg/Kg iv qd + Ursodeoxycholic Acid 250mg po tid for 5 days
Control Group:Ursodeoxycholic Acid 250mg po tid for 5 days
Sponsors
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
14 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients following OLT from donation after Chinese citizens death; 2. Donor's aged 14 years to 60 years, recipient's aged 14 years to 65 years; 3. TBIL >171µmol/L within 7-14 days after OLT, or TBIL 51µmol/L and is still rising for at least 3 days; 4. Patients and their families have signed informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria of patient: 1. Severe sepsis 2. Postoperative graft rejection 3. Postoperative biliary complications and vascular complications 4. Primary disease recurrence after OLT 5. Postoperative hemolytic icterus 6. TBIL >171µmol/L within 7-14 days after OLT but decreasing for at least 3 days 7. Blood group incompatibility between donor and recipient 8. Allergic to glucocorticoids 9. Has a history of severe diabetes or gastric ulcer 10. Has a history of pregnancy 11. Split liver transplant recipients 12. Families are reluctant to participate in the study or have not signed informed consent form. Exclusion criteria of donor: 1. Aged>60-year-old; 2. HBV or HCV infection; 3. Gilbert syndrome; 4. Weight of graft is less than 0.8% of recipient's weight; 5. Find parasites in graft.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total bilirubin; | — |
Countries
China
Contacts
Public ContactHe Xiaoshun
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed