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Intra-articular injection of magnesium sulfate in chronic knee calcium pyrophosphate deposition disease: a randomised double-blind controlled trial

Intra-articular injection of magnesium sulfate in chronic knee calcium pyrophosphate deposition disease: a randomised double-blind controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IPR-16009314
Enrollment
Unknown
Registered
2016-10-04
Start date
2017-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

calcium pyrophosphate deposition disease

Interventions

Placebo group:Intra-articular injection of 2ml 0.9% saline solution
Magnesium sulfate group:Intra-articular injection of 2ml 5% Magnesium sulfate

Sponsors

Xiangya Hospital, Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 79 Years

Inclusion criteria

Inclusion criteria: 1. Definite calcium pyrophosphate deposition disease using the McCarty diagnostic criteria; 2. Recurrent arthritis (pseudogout) (at least three flares/six months) in the target knee.

Exclusion criteria

Exclusion criteria: 1. Allergic to the agents; 2. A diagnosis of an alternative rheumatic condition: rheumatoid arthritis, psoriatic arthritis, gout et al.; 3. Calcium pyrophosphate deposition disease in bilateral knee; 4. Any acute or chronic infection of the target knee; 5. Serious illness of the heart, lung, and other vital organs.

Design outcomes

Primary

MeasureTime frame
VAS pain score;Number of analgesic pills;—

Secondary

MeasureTime frame
Function;Duration of morning stiffness;Swelling;Patient’s global assessment;X-ray assessment;Adverse events;—

Countries

China

Contacts

Public ContactGuanghua Lei

Xiangya Hospital, Central South University

lgh9640@sina.cn+86 0731-84327326

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026