vascular cognitive impairment
Conditions
Interventions
Group A:Dengzhan Shengmai Jiaonang
Group B:placebo
Sponsors
Centre for Beijing Aging Brain Rejuvenation initiative.Beijing Normal University
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: All the following 7 items are required to be met: 1. Accord with likely VaD diagnosis established by DSM-V or NINDS-AIREN or vascular cognitive impairment; 2. Hachinski ischemia scale score more than 4; 3. There is clear history of ischemic stroke or multipleh lacunar infarction,leukoencephalopathy as well as multipleh brain microbleeds confirmed by MRI; 4. MMSE score more than 11 less than 26, in accordance with mild or moderate diagnosis of cognition impairment; 5. Aged between 45 to 80; 6. The patients are voluntary to participate in clinical trial and signed the informed consent; 7. There is certain cultural degree, Cooperate with project research and scale test.
Exclusion criteria
Exclusion criteria: Subjects would be excluded when complied any of following items: 1. Degenerative dementia sunch as AD,FTD,DLB etc.; 2. Hachinski ischemia scale score less than 4; 3. Hamilton's depression scale score more than 17depressionpsychosismental disorders; 4. Having disease disturbed cognitive function evaluation, including addicted to drinking, drug and psychotropic medications during the past five years; 5. Severe neurological function deficit that can not finish the related examine,such as convenient hand hemiplegia, aphasia, visual and hearing difficulty; 6. ever used similar drugs in the past 30 days, such as antagonism drugs,psychiatric drugs, oral anticoagulants,blood-activating and stasis-eliminating compound,and short-acting diazepam; 7. Patients can not be performed with MRI which has accepted pacemaker surgery, coronary intervention surgery or coronary artery bypass surgery; 8. Allergy to drug used in this trial; 9. Participate in other clinic drug trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's disease assessment scale, ADAS-cog;Mini-Mental Status Examination;Trail Making Test;Stroop Color-word Test;Clock Drawing Test;Auditory Verbal Learning Test;Rey-Osterrich Complex Figure Test;Symbol Digit Modalities Test;Verbal Fluency Test;Boston Naming Test;Montreal Cognitive Assessment scale, MoCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIH Stroke Scale;activity of daily living; | — |
Countries
China
Contacts
Public ContactZhanJun ZHANG
Centre for Beijing Aging Brain Rejuvenation initiative.Beijing Normal University
Outcome results
None listed