postoperative cognitive dysfunction
Conditions
Interventions
control group:normal saline
dexmedetomidine group:dexmedetomidine
Sponsors
Department of Anesthesiology, First Affiliated Hospital of Inner Mongolia medical university
Eligibility
Sex/Gender
All
Age
60 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged between 60 to 65 years old, diagnosed with primary hypertension for one year or longer (BP=140/90), American Society of Anaesthesiologists (ASA) grade II or III, ready for elective gastrointestinal surgery; 2. Body weight between 45kg and 75kg, body mass index (BMI) between 19 kg/m2 and 24 kg/m2; 3. The health conditions of the subjects evaluated to be generally well according the medical history, physical examination, laboratory tests. No signs of difficult intubation. No obvious mental disorders; 4. Normal cognitive function, MMSE score > 27 points; 5. Normal ST segment in preoperative electrocardiogram (ECG).;Inclusion criteria: 1. Subjects aged between 60 to 65 years old, diagnosed with primary hypertension for one year or longer (BP=140/90), American Society of Anaesthesiologists (ASA) grade II or III, ready for elective gastrointestinal surgery; 2. Body weight between 45kg and 75kg, body mass index (BMI) between 19 kg/m2 and 24 kg/m2; 3. The health conditions of the subjects evaluated to be generally well according the medical history, physical examination, laboratory tests. No signs of difficult intubation. No obvious mental disorders; 4. Normal cognitive function, MMSE score > 27 points; 5. Normal ST segment in preoperative electrocardiogram (ECG).;Inclusion criteria: 1. Subjects aged between 60 to 65 years old, diagnosed with primary hypertension for one year or longer (BP=140/90), American Society of Anaesthesiologists (ASA) grade II or III, ready for elective gastrointestinal surgery; 2. Body weight between 45kg and 75kg, body mass index (BMI) between 19 kg/m2 and 24 kg/m2; 3. The health conditions of the subjects evaluated to be generally well according the medical history, physical examination, laboratory tests. No signs of difficult intubation. No obvious mental disorders; 4. Normal cognitive function, MMSE score > 27 points; 5. Normal ST segment in preoperative electrocardiogram (ECG).;Inclusion criteria: 1. Subjects aged between 60 to 65 years old, diagnosed with primary hypertension for one year or longer (BP=140/90), American Society of Anaesthesiologists (ASA) grade II or III, ready for elective gastrointestinal surgery; 2. Body weight between 45kg and 75kg, body mass index (BMI) between 19 kg/m2 and 24 kg/m2; 3. The health conditions of the subjects evaluated to be generally well according the medical history, physical examination, laboratory tests. No signs of difficult intubation. No obvious mental disorders; 4. Normal cognitive function, MMSE score > 27 points; 5. Normal ST segment in preoperative electrocardiogram (ECG).;Inclusion criteria: 1. Subjects aged between 60 to 65 years old, diagnosed with primary hypertension for one year or longer (BP=140/90), American Society of Anaesthesiologists (ASA) grade II or III, ready for elective gastrointestinal surgery; 2. Body weight between 45kg and 75kg, body mass index (BMI) between 19 kg/m2 and 24 kg/m2; 3. The health conditions of the subjects evaluated to be generally well according the medical history, physical examination, laboratory tests. No signs of difficult intubation. No obvious mental disorders; 4. Normal cognitive function, MMSE score > 27 points; 5. Normal ST segment in preoperative electrocardiogram (ECG).
Exclusion criteria
Exclusion criteria: 1. Significant arrhythmias, atrioventricular block, liver dysfunction, kidney dysfunction, pulmonary disease, endocrine disease, any other diseases or pathological conditions that can interfere with the experimental results; 2. Serious hearing, visual impairment or other conditions that hamper communication with the subjects; 3. Long-term administration of sedative(s), hypnotic(s), antidepressant(s); 4. A history of cerebral infarction, other central nervous system diseases, organic brain diseases or mental illness; 5. Alcohol or drug addiction; 6. Known allergy to study drugs; 7. Secondary hypertension.;Exclusion criteria: 1. Significant arrhythmias, atrioventricular block, liver dysfunction, kidney dysfunction, pulmonary disease, endocrine disease, any other diseases or pathological conditions that can interfere with the experimental results; 2. Serious hearing, visual impairment or other conditions that hamper communication with the subjects; 3. Long-term administration of sedative(s), hypnotic(s), antidepressant(s); 4. A history of cerebral infarction, other central nervous system diseases, organic brain diseases or mental illness; 5. Alcohol or drug addiction; 6. Known allergy to study drugs; 7. Secondary hypertension.;Exclusion criteria: 1. Significant arrhythmias, atrioventricular block, liver dysfunction, kidney dysfunction, pulmonary disease, endocrine disease, any other diseases or pathological conditions that can interfere with the experimental results; 2. Serious hearing, visual impairment or other conditions that hamper communication with the subjects; 3. Long-term administration of sedative(s), hypnotic(s), antidepressant(s); 4. A history of cerebral infarction, other central nervous system diseases, organic brain diseases or mental illness; 5. Alcohol or drug addiction; 6. Known allergy to study drugs; 7. Secondary hypertension.;Exclusion criteria: 1. Significant arrhythmias, atrioventricular block, liver dysfunction, kidney dysfunction, pulmonary disease, endocrine disease, any other diseases or pathological conditions that can interfere with the experimental results; 2. Serious hearing, visual impairment or other conditions that hamper communication with the subjects; 3. Long-term administration of sedative(s), hypnotic(s), antidepressant(s); 4. A history of cerebral infarction, other central nervous system diseases, organic brain diseases or mental illness; 5. Alcohol or drug addiction; 6. Known allergy to study drugs; 7. Secondary hypertension.;Exclusion criteria: 1. Significant arrhythmias, atrioventricular block, liver dysfunction, kidney dysfunction, pulmonary disease, endocrine disease, any other diseases or pathological conditions that can interfere with the experimental results; 2. Serious hearing, visual impairment or other conditions that hamper communication with the subjects; 3. Long-term administration of sedative(s), hypnotic(s), antidepressant(s); 4. A history of cerebral infarction, other central nervous system diseases, organic brain diseases or mental illness; 5. Alcohol or drug addiction; 6. Known allergy to study drugs; 7. Secondary hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE scores;The levels of IL-6, TNF-a and CRP;The NSE levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| HR, SBP, DBP, and ST segment changes in ECG; | — |
Countries
China
Contacts
Public ContactWeidong Mi;Weidong Mi;Weidong Mi;Weidong Mi;Weidong Mi ;;;;
Chinese PLA General Hospital;Chinese PLA General Hospital;Chinese PLA General Hospital;Chinese PLA General Hospital;Chinese PLA General Hospital
Outcome results
None listed