postoperative cognitive dysfunction
Conditions
Interventions
low-dose Dex group:low-dose dexmedetomidine
high-dose Dex group:high-dose dexmedetomidine
control group:normal saline
Sponsors
Department of Anesthesiology, First Affiliated Hospital of Inner Mongolia medical university
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. An informed consent; 2. Patients receiving elective surgery under general anaesthesia with OLV (thoracotomy and thoracoscopy, operation time no more than 6h); 3. American Society of Anaesthesiologists (ASA) grade I-III; 4. Aged 55 to 75 years; 5. BMI 18-25 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Systolic blood pressure =180 mmHg or <90 mmHg, diastolic blood pressure =110 mmHg or <60 mmHg; 2. Serious heart, liver, kidney, lung, endocrine diseases or severe infection; 3. Expected potential or previous difficult airway; 4. A history of abnormal anesthesia; 5. Malignant hyperthermia tendency; 6. Administration of sedatives, antidepressants, or severe alcoholism; 7. Mini Mental State Examination (MMSE) score =17 points; 8. Education level lower than Grade 6 in elementary school; 9. Severe vision disorder, dysaudia or mental instability, mental illness or other conditions that hamper communication; 10. A history of shock; 11. Patients with carotid stenosis or a history of central nervous system diseases, like stroke and epilepsy; 12. Allergic to the study drug or other contraindications; 13. Participation in the clinical study of other drug(s) over the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE score;auditory verb learning test , controlled word association test, language continuity test , digital symbol substitution test, trail making test A, trail making test B , shape matching test D, shape matching test ND, self-rating anxiety scale, and self-rating depression scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| pulse, oxygen saturation of blood,heart rate (HR), systolic blood pressure, diastolic blood pressure, end-tidal carbon dioxide partial pressure (PETCO2), airway pressure and blood gas analysis;perioperative blood transfusion amount, fluid intake and output, the overall operation time, OLV time, two-lung ventilation time, intraoperative drug dosage and dosage of analgesics used for postoperative pain management; | — |
Countries
China
Contacts
Public ContactYaying Xie
First Affiliated Hospital of Inner Mongolia medical university
Outcome results
None listed