Amnestic mild cognitive impairment
Conditions
Interventions
A group:test drug
Sponsors
Dongzhimen hospital,Beijing Univercity of Chinese Medcine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjective memory complaints confirmed by others; 2. The objective memory loss of the inconsistent with the age; 3. The cognitive function at the normal leve; 4. ADL at the normal leve; 5. no dementia; 6. The spleen and kidney deficiency syndrome; 7. Aged from 55 to 85 years; 8. Sufficient visual and auditory resolution acceptable neuropsychological tests; 9. There is a certain level of education, read simple texts and write simple sentences; 10. Patients sign informed consent.
Exclusion criteria
Exclusion criteria: 1. naMCI; 2. Dementia caused by various factors according with diagnostic criteria for dementia (DSM-IV-R); 3. Sleep disorder ; overreliance on drug or alcohol within 5-year-long, etc. leading to cognitive performance; 4. CT or MRI scan showed the central nervous system infection, infarction, other focal damage in the past 12 months; Haijinsiji Ischemic Scale (HIS) > 4 points; 5. The cases which are not suitable in this study are as follow: being high blood pressure patients still though taking corresponding drugs; patients with serious arrhythmia or with or cardiac function grade 3 ~ 4; patients suffering from myocardial infarction before attending the test; 6. The patient having used a cholinesterase inhibitor or Memantine during the past month or the patients being not qualified by screening out; 7. Patients taking Chinese medicine, Anticholinergics, anticonvulsants, anti-Parkinson drugsexcitability drugs,anticholinergics, antipsychotics, or anticholinergic drugs or pro-cholinergic effects of antidepressants or anti-anxiety drugs at the same time and those knowing to be allergic to these; 8. Patients showing severe liver and kidney dysfunction, such as liver function (ALT and AST) 1.5 times over upper level of standard range, or creatine being above standard range; 9. Patients with severe asthma and chronic obstructive pulmonary disease (COPD); 10. Patients with Serious indigestion, gastrointestinal obstruction, gastric or duodenal ulcer etc; 11. Patients taking part in other clinical research; 12. Subjects being identified as disobedient by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ADAS-cog;CDR; | — |
Secondary
| Measure | Time frame |
|---|---|
| DSR;MMSE;ADCS-MCI-ADL;CGIC-PES; | — |
Countries
China
Contacts
Public ContactJing Shi
Dongzhimen hospital,Beijing Univercity of Chinese Medcine
Outcome results
None listed