Children antibiotic-associated diarrhea(ADD)
Conditions
Interventions
Test group:Antibiotics and Bacillus Viable particles
control group:Antibiotic and Placebo blank
Sponsors
Shenzhen Children's Hospital
Eligibility
Sex/Gender
All
Age
0.1 Years to 3 Years
Inclusion criteria
Inclusion criteria: (1) January to 3 year old children; (2) no diarrhea symptoms; (3) diagnosis of respiratory tract infections (acute bronchitis, pneumonia) of Hospitalized children; (4) requires penicillins, cephalosporins antibiotic therapy, treatment course of 7 to 14 days, alone in combination with other antimicrobial agents; (5) a parent or guardian to sign an informed consent form; (6) not used in children related to traditional Chinese medicine injection preparation.
Exclusion criteria
Exclusion criteria: (1) Diarrhea occurs when the group, or the group 2 before happened last week with diarrhea; (2) ICU ward children, gastrointestinal malformations, gastrointestinal surgery in children with congenital heart disease, valvular artificial heart surgery in children with rheumatoid heart disease, infective endocarditis; (3) Treated by immunized inhibitors children; (4) Children received any probiotic preparations in past two weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of diarrhea (Daily stool frequency and character ratings);Time of occurrence of diarrhea;The degree of diarrhea; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal flora and related metabolites;Microenvironment; | — |
Countries
China
Contacts
Public ContactYuejie Zhen
Shenzhen Children's Hospital
Outcome results
None listed