Post Operative Cognitive Dysfunction
Conditions
Interventions
treatment group:ulinastatin
control group:saline
Sponsors
XuanWu Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: treatment group: ASA III or less, aged 65-80 years old, no gender unlimited, line of lumbar spinal decompression or fixation; control group: health old participants.
Exclusion criteria
Exclusion criteria: 1) mental disorder or mental illness (depression)>16; 2) severe alcoholism, drug abuse; 3) simple preoperative mental state examination (MMSE) is 23 or less; 4) renal impairment (Cr > 177 umol/L), active liver disease; 5) serious eyesight or hearing impairment; 6) illiteracy, or can't communicate with physicians; 7) the WBC > 10000x10^9/L, abnormal urine routine test; 8) tumor diseases, acute trauma or inflammatory disorders; 9) the cardiovascular disease such as myocardial infarction within 6 month; 10) history of cerebrovascular diseases including cerebral hemorrhage or cerebral embolism within 6 month or with neurological sequelae; 11) brain tumors; Epilepsy; Parkinson's disease, and etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LPS;IL-6;CRP;MMP-9; | — |
Countries
China
Contacts
Public ContactTianlong Wang
XuanWu Hospital of Capital Medical University
Outcome results
None listed