lung cancer
Conditions
Interventions
endostar monotherapy group:endostar monotherapy
endostar combined cisplatin group:endostar combined cisplatin
Cisplatin monotherapy group:Cisplatin monotherapy
Sponsors
Chongqing Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Malignant pleural effusion was confirmed by pathological examination; 2. Merger of medium dose or amount of the above pleural effusion, (ultrasound shows hydrothorax maximum diameter 4 cm or higher)First treatment or conventional chemotherapy drugs and/or biological response regulator is invalid;(note: ultrasound tip 4 cm or less for a small amount of effusion, 4-6 cm for the amount of effusion, 6 cm for a large number of effusion or higher) 3. Aged 18 to 80 years; 4. KPS > 60 points; 5. Expected to survive more than 3 months; 6. The main organ within 7 days before the treatment, meet the following criteria: 1) Blood routine standard (No blood transfusion within 14 days); Hemoglobin (HB) was 90 g/L or higher; Neutrophils absolute value (ANC) acuity 1.5 x 10^9/L; The platelet (PLT) = 80 x 10^9/L; 2) Biochemical inspection standard: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) or less 2 times the upper limit of normal (ULN), such as with liver metastasis, ALT and AST 5 x ULN or less; Total bilirubin (TBIL) was 1.5 x ULN or less; Serum creatinine (Cr)was 1.5 x ULN or less or creatinine clearance (CCr) or 60 ml/min; 7. Patients volunteered for the study, signed informed consent; 8. more than 4 weeks from major surgery 9. more than 4 weeks from the end of the radiation and chemotherapy.
Exclusion criteria
Exclusion criteria: 1. Used other studied drugs within 30 days, or in other clinical research at the same time; 2. Less than six months after myocardial infarction, or have unstable angina and cardiac insufficiency at present; 3. With severe chronic obstructive pulmonary disease (copd) and/or respiratory failure, severe intestinal adhesion; 4. Patients with poor compliance, or suffering from mental illness; 5. known allergic to this experimental drug and its accessories; 6. Activity or failed to control the serious infection; 7. Pregnant patients or patients with nursing, don't want to take contraceptive measures of reproductive age patients (including men); 8. Not the malignant pleural effusion.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Quality of life;Adverse reactions; | — |
Primary
| Measure | Time frame |
|---|---|
| Objective response rate; | — |
Countries
China
Contacts
Public ContactHuiqing Yu
Chongqing Cancer Hospital
Outcome results
None listed