nonalcoholic fatty liver disease
Conditions
Interventions
treantment group:Levocarnitine 1g, bid., po., 12wks
2:no
Sponsors
Beijing Youan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-70 years old; 2. NAFLD patients meet the diagnosis criteria according to: The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association); 3. ALT 60 to 250 U/L; 4. Patient signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1) fatty liver caused by a specific cause, such as tamoxifen; 2) combined with other causes of liver disease such as viral hepatitis (such as HBsAg or anti HCV positive), liver cirrhosis, drug-induced liver injury, autoimmune diseases, metabolic liver disease, etc; 3) Alcohol abuse, alcohol consumption >70g/week for female patient or >140g/week for male patient; 4) Patient who is receiving insulin treatment; 5) patients with severe disease of other system, mental disease, or senile dementia patients, epilepsy patients; hypothyroidism or Cushing's syndrome; 6) Have received Levocarnitine treatment within 30 days; Hypersensitive to Levocarnitine and its derivatives; 7) Patient has participated in other drug clinical trial within 30 days; 8) use of drugs such as calcium channel blockers, high dose of synthetic estrogens, methotrexate, amiodarone steroids, chloroquine; 9) Pregnant or lactating female, or female of childbearing potential does not use adequate contraceptive methods; 10) other situations that researchers think the patient is not suitable for the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALT level; | — |
Secondary
| Measure | Time frame |
|---|---|
| GGT;the ration of patients whose ALT decrease to normal;AST;HOMA-IR;TG;TC;HDL-C;LDL-C;Fasting blood glucose;CAP; | — |
Countries
China mainland
Contacts
Public ContactJing Zhang
Beijing Youan Hospital, Capital Medical University
Outcome results
None listed