breast cancer
Conditions
Interventions
Group 2:metformin,850mg,Bid.
Sponsors
Department of Endocrine and Breast Surgery of the First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Volunteered for this study and informed consent was abtained from the participants; 2. Female and age from 20 to 70 years old; 3. Diagnosis as breast cancer according to clinical practice guideline; 4. Indications for neoadjuvant chemotherapy according to clinical practice guideline: clinical I/II stage breast cancer; 5. Diagnosis as prediabetes: OGTT examinations show IFG 5.6-6.9mmol/L, IGT 7.8-11.0mmol/L; Or HbA1c:5.7-6.4%.
Exclusion criteria
Exclusion criteria: 1. History of diabetes; 2. History of hypoglycemic agent use; 3. Pregnant or breast feeding women; 4. BMI=35kg/m2; 5. Liver and renal function abnormal obviously(ALT greater than 2.5 times of upper bound, or eGFR180mmHg or diastolic pressure>110mmHg); 7. Coexistence of serious heart diseasecardiac function II or aboveanemia(Hb<9.0g/dl); 8. Alcoholismdrug abuse and mental disorder; 9. Coexistence of digestion and absorption dysfunction and other endocrine diseases; 10. Coexistence of other chronic disease and need to treat with glucocorticoid; 11. Coexistence of other serious medical conditions, such as serious infections, organs failure, serious injury, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathologic complete response(PCR); | — |
Secondary
| Measure | Time frame |
|---|---|
| breast cancer events;Clinical recession of lump;Glucose intolerance and insulin function status;Metabolic syndrome; | — |
Countries
China
Contacts
Public ContactRen Guo-sheng
Department of Endocrine and Breast Surgery of the First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed