Alzheimer Disease
Conditions
Sponsors
Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 55-80 years old (including 55 and 80 years of age), no limitation of sex; 2. In accordance with the diagnostic criteria for "mild cognitive impairment due to alzheimer's disease" from National Institutes of Health National Institute on Aging-Alzheimer's Association (NIA - AA) (2011); 3. There are insufficiency in one or more cognitive domains. MMSE 24-28 points. Patients does not meet diagnostic criteria for dementia (DSM-IV-R); 4. The Hamilton depression rating scale / 17 edition (HAMD) total score70 years, white matter damage rating scale<=2; Lacunar infarcts larger than 2 cm in diameter<= 2; no infarcts in important parts such as the hypothalamus, entorhinal cortex, para-hupothalamus, cortical and subcortical cavity infarction near gray matter nuclei. The the MTA atrophy classification: grade II or above; 9. Neurological examination: no obvious signs; 10. Participants should have the caregiver stable and reliable. They contact frequently (at least 4 days a week, at least 2 hours per day), and caregivers will help patients to participate in the research process. Caregivers must accompany the participants in every visit, and must have good interaction with the subjects, in order to provide valuable information in ADCS - ADL, NPI rating scale; 11. Education: primary school (grade 6) or above. They have the ability to complete tests for cognitive ability, and have ability and time to complete regulation of cognitive training; 12. Before any examination or operation, subjects and their legal caregiver must sign written informed consent. If one cannot sign due to limited cognitive ability, we allow blank in subjects signing place. We need to explain the reason, and then ask for sign by the legal caregiver for the reasons. At the same time, the legal caregiver must sign a consent form.
Exclusion criteria
Exclusion criteria: 1. Other causes of cognitive decline: cerebrovascular disease, central nervous system infection, CJD, huntington's and Parkinson's disease, DLB, traumatic brain dementia, other physical and chemical factors (such as drugs, alcohol, CO), systemic disease (hepatic encephalopathy, pulmonary encephalopathy, etc.), intracranial occupation (a subdural hematoma, brain tumor), the endocrine system disease (thyroid disease, parathyroid disease), and vitamins deficiency or any other causes of dementia; 2. The history of nervous system diseases, including stroke, optic myelitis, Parkinson's disease, epilepsy, etc.); 3. Psychiatric patients, including schizophrenia or other mental illnesses, bipolar disorder, major depression or delirium; 4. There are abnormal laboratory indexes: liver function (ALT and AST) 1.5 times over upper level of standard range, creatine 1.5 times over upper level of standard range, moderate or severe anemia, fasting blood glucose value more than 1.5 over upper level of standard range; 5. Systolic blood pressure > 160 mmHg or 100 mmHg or < 60 mmHg; 6. There are unstable or serious heart, lung, liver, kidney, hematopoietic system disease; Poor prognosis because of malignant diseases such as tumor; 7. Vision or hearing problems that lead to poor performance of cognitive test; 8. Two years history of severe alcoholism, drug abuse; 9. Participated in other clinical trials within 30 days before the screening; 10. The researchers believe that the subjects could not complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AD incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| ADAS-Cog Score;ACE-R score;NPI;ADCS-ADL; | — |
Countries
China
Contacts
Public ContactShengdi Chen
Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed