acute pancreatitis
Conditions
Interventions
experimental:esomeprazole 40mg/d
PPI-N group:conventional medical management
volunteers group:none
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with acute pancreatitis; 2. The duration of the disease<= 72 hours (begin with the onset of abdominal pain); 3. Aged between 18 and 65 years old; 4. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. treatment with anti-acid agents or prokinetic drug during the past four weeks; 2. regular medicine treatment of antibiotics, NSAIDS, antidepressant, and immune suppression treatment; 3. history of enteroscopy during the past 1 month and history of chronic diarrhea, malabsorption, irritable bowel syndrome, inflammatory bowel disease; 4. organ failure, diabetes, thyroidea diseases, scleroderma and any other combined disease can influnce the intestinal mobility; 5. gastrointestinal operation and history of ileus; 6. Pregnant women and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gastric pH;the prevalence of SIBO;change of gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| index of inflammation;prevalence of infection;index of radioimmunity;modified CTSI;hospital stay;cost of hospitalization ;duodenum pH;prevalence of GI bleeding;APACHE II score; | — |
Countries
China
Contacts
Public ContactChengwei Tang
Department of Gastroenterology, West China Hospital, Sichuan University
Outcome results
None listed