Effects of dexmedetomidine on brain injury in the patients undergoing open heart surgery during cardiopulmonary bypass

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-16008169

Enrollment

Unknown

Registered

2016-03-27

Start date

2016-03-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac surgical diseases

Interventions

Conventional CPB group:Conventional anesthetics

Dexmedetomidine CPB I group:Low-dose dexmedetomidine + conventional anesthetics

Dexmedetomidine II group:Middle-dose dexmedetomidine + conventional anesthetics

Dexmedetomidine CPB III group:High-dose dexmedetomidine + conventional anesthetics

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-70 years old, male or female; 2. patients undergoing open heart surgery during cardiopulmonary bypass.

Exclusion criteria

Exclusion criteria: Patients had stroke, brain surgery, neurological dysfunction, cardiovascular surgeryx, cardiac insufficiency more than one year, severe liver and kidney dysfunction before operation.

Design outcomes

Primary

Measure	Time frame
interleukin-6;interleukin-10;S100ß protein;NSE;	—

Countries

China

Contacts

Public ContactXie Yu Bo

First Affiliated Hospital of Guangxi Medical University

xieyubo715001@aliyun.com+86 13977121557

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026