nonalcoholic fatty liver disease
Conditions
Interventions
Control group:placebo
Proanthocyanidins+Vc+Ve group:Proanthocyanidins+Vc+Ve
Sponsors
Third Military Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: According to criteria recommended by the Chinese Society Hepatology, CMA in 2010, nonalcoholic fatty liver disease patients was diagnosed as: 1. No alcohol intake or alcohol consumption was less than 140g/weeks (female g/ <70 weeks), and 2. No special diseases which can lead to fatty liver such as viral hepatitis, Drug induced liver disease,total parenteral nutrition, hepatolenticular degeneration, autoimmune liver disease and et al.; 3. In addition to the clinical manifestations of primary disease, they also have nonspecific symptoms and signs such as Weak, indigestion, liver area pain, hepatosplenomegaly etc.; 4. Patients with metabolic syndrome,appear serum ALT and (or) AST, GGT continued to increase for more than half a year for unknown reason; 5. Liver imaging performance was consistent with the diagnostic criteria of diffuse fatty liver and had no other reasons; 6. histology of liver biopsy accord with criteria for the diagnosis of fatty liver disease. And subjects also meet the following criteria: 1. Aged between 20 to 60 years; 2. diagnosed with NAFL or mild, moderate NASH and no drug therapy; 3. BMI(20~30),Body weight stability in the past three months; 4. Fasting blood glucose<7.8mmol/L5; 5. meet all ethical requirements and sign the informed consent form, live in Chongqing in the next 4 months and vist to the hospital conveniently.
Exclusion criteria
Exclusion criteria: 1. excessive drinking,hepatitis B virus infected patients,or Non local permanent residents; 2. Taking drugs which affect the metabolism of blood lipid in the past six months; 3. Gastrointestinal disease patients,all kinds of chronic disesses, liver and kidney dysfunction patients; 4. Acute and chronic infectious disease, trauma or surgery before the previous month of the study; 5. Patients with poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total triglyceride;total cholesterol;Low density lipoprotein cholesterol;High density lipoprotein cholesterol;ALT;AST;GGT; | — |
Secondary
| Measure | Time frame |
|---|---|
| GLU;albumin;total protein;creatinine;urea;uric acid; | — |
Countries
China
Contacts
Public ContactMi Mantian
Third Military Medical University
Outcome results
None listed