Mild to moderate psoriasis
Conditions
Interventions
test group:Compound Clobetasol Propionate Ointment group, 2 times a day, continuous treatment for 4 weeks, the local external use for psoriasis
control group:Calcipotriol Betamethasone Ointment group, 1 times a day, for 4 consecutive weeks. The local external for psoriasis.
Sponsors
The First Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) The informed consent has been signed in; 2) Patients who were 18~65 years of age, stable psoriasis patients, the gender is not limited; 3) The lesion area does not exceed 10% of the total surface area of the body; 4) The overall evaluation of the researchers (PGA) = 2; 5) The observation of target lesions of minimum diameter greater than or equal to 2cm.
Exclusion criteria
Exclusion criteria: 1) Patiens who were suspected of being allergic to the composition of the drug; 2) Patiens who were diagnosed as non psoriasis vulgaris (such as erythrodermic type, pustular psoriasis, arthritis), and psoriasis; 3) There are severe central nervous system, cardiovascular system, kidney, liver, digestive tract, respiratory system, metabolism and skeletal muscle system and mental disorders; 4) Patients with other diseases may affect the efficacy of the judge: such as eczema, etc.; 5) Liver function (ALT, AST) is more than 2 times the upper limit of normal, or renal function (Cr) is more than 1.5 times the upper limit of normal value; 6) Hypercalcemia serum calcium values exceed the upper limit of the normal value of patients), or have the possibility of disease caused by hypercalcemia; 7) Patiens who are taking affect calcium metabolism of drugs (the serum calcium values increased drug: containing calcium preparation, medication in the active form of vitamin D3, injection, anabolic agents (ipriflavone preparations); the serum calcium values to lower drug: calcitonin preparation, double phosphate ester compound preparation, sex hormone preparations) patients. 8) Patiens who were randomly divided into group had received systemic biological treatment (listed or unlisted), such as: within 12 weeks ago receive ustekinumab, within 8 weeks ago received infliximab, adalimumab, within 4 weeks ago received etanercept and so on; 9) Patiens who were randomly divided into groups of 4 weeks or test accepted abiotic systemic therapy may have an effect on psoriasis persons, including, but not limited to vitamin A preparations, cortical hormone, vitamin D analogs, immunosuppressant, compound glycyrrhizin, traditional Chinese medicine and so on. 10) Patients who were randomly enrolled received PUVA treatment within weeks of the first 4 weeks of the trial or randomly assigned to a group of 11 weeks before or during the study period received ultraviolet therapy, topical treatment of psoriasis drugs; 11) Patiens who were randomly divided into groups of 2 weeks worked or research plan during the use of psoriasis with drugs, such as: beta blockers, antimalarial drugs, lithium preparations, and so on; 12) Patiens who were randomly assigned to participate in other clinical trials in the first 13 weeks; 13) Patiens who acceptd for a long time in outdoor work to accept the sun, may have an impact on the diagnosis and treatment of this disease; 14) Lactation, pregnancy, and not to take effective contraceptive measures of women of childbearing age; 15) People who are known or suspected poor compliance can not be completed, such as alcoholism, drug dependence or mental illness, etc., the researchers are not suitable to participate in the clinical investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficiency of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cure rate, effective rate, curative effect composition, SSRI improvement rate, treatment 4 weeks PASI response rate (PASI 75), treatment 4 weeks PGA response rate (PGA basic regression rate);routine blood test;Urine routine;blood biochemical indeces; | — |
Countries
China
Contacts
Public ContactXing-hua Gao
1st affiliated hospital of China medical university
Outcome results
None listed