Osteoarthritis
Conditions
Interventions
treatment group:zu shi ma plasters 24 treatment group and 24h group
treatment group:Zu Shi Ma plasters 12h treatment group
control group:Indomethacin Papua paste 24 h treatment group
Sponsors
Ethics Committee of Guang'anmen Hospital of China academy of traditional Chinese medicine
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) comply with knee Osteoarthritis diagnostic criteria; (2) aged 40 to 75 years old; (3) Accepted the NSAID pain medications, or before (such as acetaminophen non-steroidal anti-inflammatory drug, or contains the pain of non-prescription drugs, or may contain analgesic active ingredients of traditional Chinese medicine) of the patients have been 1 week cleaning period, patients and doctors to arthritis overall assessment for the "general, poor or very poor"; Patients with arthritis pain VAS score 20 mm or higher ground to walk, and compared with the screening when pain increases at least 10 mm;Compared with the screening of the overall assessment level 1 or above;Overall assessment level 1 or above; (4) 1 week before no NSAID pain medications or, the ground walk arthritis pain VAS score 40 mm or greater, the overall assessment of the patients and doctors to arthritis for "poor or very poor"; (5) signed informed consent.
Exclusion criteria
Exclusion criteria: (1) do not conform to the knee osteoarthritis western medicine diagnostic criteria; (2) the knee is swollen; (3) the knee joint with crystalline synovial inflammation (joints), acute inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, suppurative arthritis, systemic lupus erythematosus (sle) and sjogren's syndrome, vasculitis, rheumatic diseases such as inflammatory arthritis and metabolic bone disease caused by endocrine disease; (4) injury of knee joint cartilage and ligament damage, tuberculosis, tumour, fracture, deformation osteitis (paget bone disease), severe dysplasia or congenital anomalies, browns, acromegaly, hemochromatosis disease, liver degeneration disease, primary cartilage tumour disease, etc.; (5) merge heart, brain, liver, kidney and hematopoietic system, such as serious illness;Pregnancy, ready for pregnancy or lactation women, psychiatric patients;Doubt or have alcohol and drug abuse history; (6) 2 months prior to screening received systemic hormone therapy or joint cavity or 2 months for knee arthroscopy;6 months prior to screening knee arthritis with trauma or surgery, or knee joint has a history of three or more trauma or surgery; (7) All landowners to any ingredient in the drug allergy (father of hemp, ZhangDan monk, sesame oil, yellow). (8) Today is in other clinical studies; (9) Pathological changes of pet-name ruby damaged skin or skin or skin allergies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC score; | — |
Countries
China
Contacts
Public ContactJiang Quan
Rheumatism of hospital of China academy of traditional Chinese medicine
Outcome results
None listed