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A Randomized Controlled Trial of Conbercept Pretretreatment before Vitrectomy in Proliferative Diabetic Retinopathy

The efficacy and safety of preoperative intravitreal conbercept (IVC) injection before vitrectomy for proliferative diabetic retinopathy

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IPR-16007848
Enrollment
Unknown
Registered
2016-01-28
Start date
2014-01-02
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetic retinopathy

Interventions

intravitreal conbercept group vs control group:intravitreal conbercept injection

Sponsors

The First People's Hospital of Yunnan Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: The study population consisted of male or female patients aged >=18 years with type 1 or 2 DM (per American Diabetes Association or World Health Organization guidelines), hemoglobin (Hb) A1c <=10%, and visual loss only due to non-absorbent VH, fibrovascular proliferation with vitreoretinal adhesions or tractional retinal detachment (TRD) depended on clinical ocular findings and accessory examinations who had to undergo vitrectomy.

Exclusion criteria

Exclusion criteria: Key exclusion criteria were history of coagulopathy, hypertension and stroke or transient ischemic attack; intraocular treatment with corticosteroids, anti-VEGF or intraocular surgery at any time; confirmed intraocular pressure (IOP) >=21 mmHg, glaucoma or iris neovascularization in either eye; severe retinopathy with long-acting gas or silicone oil usage during surgery; a follow-up period of fewer than 3 months.

Design outcomes

Primary

MeasureTime frame
BCVA;recurrent vitreous hemorrhage;vitreous clear-up time;

Countries

china

Contacts

Public ContactXiaochun Yang
blackstone502@163.com+86 15808825607

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026