gastoentric tumor
Conditions
Interventions
oxycodone group:perioperative analgesia with oxycodone
sufentanil group:perioperative analgesia with sufentanil
Sponsors
Department of Anesthesiology, Changzheng Hospital, Second Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Approved by the hospital ethics committee, 100 cases of laparoscopic gastric cancer and colorectal cancer surgery were selected(surgery time 2-4h). Age between 18-65, ASA I-II.
Exclusion criteria
Exclusion criteria: Patient exclusion criteria: allergic to oxycodone or Other ingredients in the preparation of oxycodone; Patients with history of respiratory disease; A long history of smoking; There were upper respiratory tract infection in the last 2 weeks; use of hormones, bronchial dilation agent in the last 2 weeks; Patients with heart ,brain, liver and kidney disease; Morbidly obese patients; The history of mental and neurological diseases was diagnosed before operation; Long term use of diazepam or opioid drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;emergence agitation;Level of sedation;The degree of pain;cough reflex;respiratory depression;blood glucose;the plasma cortisol concentration;TNF-a;IL-1ß;IL-6;IL-10;OPRM1 A118G gene polymorphism;CYP3A4 gene polymorphism;CYP3A5 gene polymorphism; | — |
Countries
China
Contacts
Public ContactYuan Hongbin
Outcome results
None listed