viral pneumonia without influenza
Conditions
Interventions
treatment group:Conventional treatment +lianhuaqingwen
placebo group:Conventional therapy + placebo
Sponsors
Beijing Ditan Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients of community-acquaired pneumonia; 2. Meet the clinical-defined virus pneumonia criteria: (1) fever; (2) respiratory symptom; with or without dyspenia; (3) normal or low leukocyte count; with or without low blood platelet count; (4) Chest radiogram manifestation: unilateral or bilateral chest radiogram test showed multiple (at least two lesions) or diffuse distribution of patchy or glass attenuation infiltrates (with or without consolidation) 3. Etiological examination confirm virus infection besides influza virus.All cases are further do digital PCR quantitative detection of the virus; 4. Onset time<=5d; 5. Ages Eligible for Study: 14-75 Years Genders Eligible for Study: Both 6. Accepts Healthy Volunteers: No 7. Willing and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Clear laboratory and clinical evidence of bacterial infection; PCT>1ug/L; 2. Use antiviral drugs within 1 week, include anti-virus herbs; 3. Patients of sever pneumonia; 4. Critical lung basic diseases, such as bronchiectasis, and interstitial lung disease confirmed by chest CT; 5. Clear laboratory evidence of Streptococcus ,Legionella pneumophila, Mycoplasma and Chlamydia infection, influza virus; 6. Severe hepatic and renal function with significant abnormalities:1)AST, ALT is over 3 times more than the upper limits of normal 2)serum creatinine is over 1.5 times more than the upper limits of normal; 7. Those diseases affect virus pneumonia progress: tumor, autoimmune diseases, hematologic disease, endocrine disease, centeral nervous system disease, hepatic disease, renal disease, as determined by the investigator; 8. Exiting affecting immune system disease, for example: HIV infection, those subjects who accept stem transplantation, splenectomy and organ transplantation; 9. History of epilepsy or other central nervous system diseases,History of alcohol abuse,History of substance abuse; 10. Pregnant or nursing; 11. Those subjects are not suitable for this study, as investigator suggests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptom; | — |
Countries
China
Contacts
Public ContactLixingwang
Outcome results
None listed