Ischemic stroke
Conditions
Interventions
Group A: receive fluoxetine 20mg per day immediately after enrollment
Group B:receive fluoxetine 20mg per day 7 days after enrollment
group C:Conventional therapy without fluoxetine
Sponsors
The Shenzhen People's hospital, Shenzhen, Guangdong, China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Adherence to the diagnostic criteria of ischemic stroke as defined by World Health Organization (WHO); (2) 18–80 years old; (3) first onset of stroke within 1 weeks; (4) symptoms of defective nervous system and National Institutes of Health Stroke Scale (NIHSS) score > 2; and (5) informed consent was obtained from all the patients or their legal relatives.
Exclusion criteria
Exclusion criteria: (1) Coma; (2) hemorrhagic stroke; (3) symptoms of defective nervous system before the onset of stroke; (4) used antidepressants within 3 months before the onset or benzodiazepines within 2 weeks before the onset; (5) considered exiting the study, self-injurious or suicidal tendency, and urgency of antidepressants; (6) serious heart diseases, respiratory failure, malignant tumor; (7) abnormal liver enzymes or creatinine; (8) active peptic ulcer or other gastrointestinal diseases, which may affect the absorption of drugs; (9) allergic constitution; (10) severe mental disorders, such as schizophrenia; (11) pregnant or lactating women; (12) participated in other clinical studies within 3 months before the study; (13) planned to receive endovascular treatment; and (14) patients or their legal relatives refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NIHSS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| BI score;Blood glucose;Blood lipids;Blood pressure;Stroke recurrence; | — |
Countries
China
Contacts
Public ContactGuo Yi
Outcome results
None listed