The effect of intraoperative dexmedetomidine on occurrence of postoperative delirium in old patients after non-cardiac major surgery

Conditions

Postoperative delirium

Li CJ, Wang BJ, Mu DL, Wang DX.

2021-05-075 citations

Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery

C.-J. Li, B.-J. Wang, D-L Mu, Jie Hu, Changlong Guo et al. (8 authors)

British journal of surgery2020-01-01104 citations

10.1002/bjs.11354

Impact of dexmedetomidine infusion during general anaesthesia on incidence of postoperative delirium in elderly patients after major non-cardiac surgery: study protocol of a randomised, double-blinded and placebo-controlled trial.

Wang BJ, Li CJ, Hu J, Li HJ, Guo C, Wang ZH, Zhang QC, Mu DL, Wang DX.

2018-04-217 citations

10.1136/bmjopen-2017-019549

Interventions

Intervention Group:Dexmedetomidine

Control Group:Normal saline

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. aged older than 60-years; 2. Patients who will undertake non-cardiac major surgery.

Exclusion criteria

Exclusion criteria: 1. refuse to join; 2. history of schizophrenia, epilepsy, parkinson disease, severe dementia; 3. History of visual or hearing dysffunction and cannot communicate; 4. History of brain damage or functional neurosurgery; 5. History of sick sinus syndrome, bradycardia(HR<40bpm), II AVB or above without pacemaker; 6. Child-pugh grade C; 7. History of renal replacement therapy; 8. planned to undertake neurosurgery.

Design outcomes

Primary

Measure	Time frame
Postoperative delirium;	—

Secondary

Measure	Time frame
Postoperative cognitive function;postoperative complications;postoperative 30-day mortality;Pain intensity;consumption of morphine;subjective sleep quality;length of stay in hospital after surgery;safety outcome;ICU admission;	—

Countries

China

Contacts

Public ContactWang Dong-xin

Department of anesthesiology, Peking University First Hospital

wangdongxin@hotmail.com+86 13910731903

Outcome results

None listed