type 2 diabetes
Conditions
Interventions
A:CSII(Aspart)
B:aspart Mix 30/70
C:Aspart+glargine
Sponsors
Nanjing First Hospital, Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. voluntary to attend this study signed the informed consent; 2. between 18 and 70 years of age; 3. according to the WHO standards, the subjects should be diagnosed as type 2 diabetes; 4. Patients with newly diagnosed diabetes,and did not up to standard with exercise control for a month; 5. Sulfonylureas failure regarding to two kinds of antidiabetic drugs with 3 years duration; 6. FBS between 7-16mmol/L and PBS<22.2mmol/L within one week; 7. BMI 18~40kg/m2; 8. Without diabetes acute complications such as diabetic ketoacidosis, hypertonic syndrome, etc.; 9. The subjects are willing to monitoring the blood glucose and controlling the diet.
Exclusion criteria
Exclusion criteria: 1. Patiens accepted other drugs during the past 3 month; 2. Impaired liver function,the alt is 2.5 times of theper limit;serum creatinine is 1.3 times greater than that of theper limit; 3. A history of drug abuse alcohol dependence in the past 5 years; 4. Recurrent hypoglycemic events; 5. using the intravenous hormone therapy; 6. Heart disease:decompensated heart failure (NYHA III type and VI type), unstable angina, cardiomyopathy; 7. Allergic to the drugs or related products (insulin, metal), or local induration in insulin injection site; 8. Pregnancy, breast-feeding,or not using enough contraception(enough refers to the intrauterine device, oral contraceptives, prevent measures); 9. Poor adherence; 10. The probabl basic diseases which may obstruct this study,such as active malignancy, cardiomyopathy, mental disease; 11. There is infection during the past 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI;waistline;hipline;blood routine examination;routine urine test;liver function;renal function;lipid;urine microalbumin;HbA1C;blood insulin;c peptide;CRP;fundus examination;Carotid ethnography;Limb doppler;6-prostaglandin of 24h; | — |
Countries
China
Contacts
Public ContactJianhua Ma
Outcome results
None listed