Subclinical hypothyroidism, infertility
Conditions
Interventions
Levothyroxine arm:Levothyroxine treatment
Sponsors
Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
Eligibility
Sex/Gender
Female
Age
20 Years to 39 Years
Inclusion criteria
Inclusion criteria: 1. Women have a duration of infertility >=1 year; 2. Women ages >=20 and <40 years old; 3. Women who are undergoing their first cycle of IVF or ICSI; 4. Women with TSH level 2.5~4mIU/L and normal free thyroxine.
Exclusion criteria
Exclusion criteria: 1. Women who are taking thyroid medicine or medicines interfering thyroid metabolism for last 2 months; 2. Women who have previously been diagnosed with a uterine abnormality such as a malformed uterus (uterus unicornis, septate uterus, duplex uterus or uterus bicomis), adenomyosis, submucous myoma or intrauterine adhesion; 3. Women or their partners with an abnormal chromosome karyotype; 4. Women with medical conditions that contraindicate assisted reproductive technology and/or pregnancy, such as poorly controlled diabetes mellitus; undiagnosed liver disease or dysfunction (based on serum liver enzyme test results); undiagnosed renal disease or abnormal serum renal function; severe anemia; history of deep venous thrombosis, pulmonary embolus or cerebrovascular accident; uncontrolled hypertension or symptomatic heart disease; history of (or suspected) cervical carcinoma, endometrial carcinoma or breast carcinoma; and undiagnosed vaginal bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate;children IQ at 60 months old; | — |
Countries
China
Contacts
Public ContactZi-Jiang Chen
Outcome results
None listed