vestibular migraine
Conditions
Interventions
T-S group:Firstly tou tong ning capsule and secondly sodium valproate administration, with a washout period in the middle
S-T group:Firstly sodium valproate and secondly tou tong ning capsule administration, with a washout period in the middle
Sponsors
Navy general hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male or female,18 years old to 65 years of age; 2. Patients are recruited meeting the International classification of headache disorders-III (ICHD-III) beta vestibular migraine criteria by International Headache Society(IHS) in 2013; 3. Frequency of two or more migraine headache attacks per month during last three months before entry; 4. Duration of at least 1 year; 5. No concomitant migraine prophylactics are taken 1 month prior to entry into this trial; 6. Participants have the ability to fulfil an accurate and reliable headache diary; 7. Body mass index(BMI) lies between 18Kg/(m^2) and 35 Kg/(m^2); 8. Informed consents of participants are obtained.
Exclusion criteria
Exclusion criteria: 1. Pregnant or breast-feeding women; 2. Severe dysfuction of liver, kidney, heart or multiple organ dysfunction; 3. Neoplastic diseases; 4. Secondary headache such as encephalitis, traumatic brain injury, hypertension headache, et al. 5. Medication-overuse headache during the last three months, defined as headache >14 days per month combined with overuse of simple analgesics in monotherapy >14 days per month or triptans or combined medications more than 10 days per month; 6. Patients with neurologic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of migraine attacks per month; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale(VAS) of headache intensity;Duration of each episode;Migraine days per month;Percentage of abnormal laboratory value; | — |
Countries
China
Contacts
Public ContactXiaokun Qi
Outcome results
None listed