early gastric cancer
Conditions
Interventions
Preoperative group:Esomeprazole 40mg iv bid*6day followed 20 mg po bid 23d
Postoperative group:Esomeprazole 40mg iv bid*5 day followed 20 mg po bid 23d
Sponsors
Union Hospital Tongji College Huazhong University of Science And Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Ages Eligible for Study: 18 Years to 80 Years; 2. Male or female; 3. Gastric early cancer or precancerous lesions of gastric cancer.
Exclusion criteria
Exclusion criteria: 1. Recent use of a PPI, H2RA, bismuth, andantibiotics; 2. Current use of aspirin, non-steroidal anti-inflammatory drugs, or corticosteroids; 3. Helicobacter pylori infection not evaluated appropriately by endoscopic biopsy andserology; 4. A history of subtotal gastrectomy; patients who underwent surgery due to ESD complications; known hypersensitivity to PPIs; 5. chronic co-morbid disease, such as chronic liver andrenal disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean percentage of time with intragastric pH>4 during 24-h period pH monitoring at day1 after ESD operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| ESD related bleeding rate during operation;ESD related bleeding rate in day 1, 2, 3,4,5 ,7and28 along with PPI treatments;Stomachache release in day 1, 2, 3,4,5 and7 along with PPI treatments;Turnover of ulcer stage andsize change of artificial ulcers at day 7 and28 compared initial operation.; | — |
Countries
China
Contacts
Public ContactHou Xiaohua
Outcome results
None listed