antibiotic-associated diarrhea (AAD)
Conditions
Interventions
intervention group:Children in the intervention group received Saccharomyces boulardii CNCM-I 457, 250 mg once a day, simultaneously with oral antibiotics and symptomatic supportive treatment., Treatm
control group:Patients in the control group received only antibiotics and symptomatic supportive treatment.
Sponsors
West China Second Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
No minimum to 3 Years
Inclusion criteria
Inclusion criteria: Male or female hospitalized children (aged from 1 month to 3 years old) with non-gastrointestinal infections requiring antibiotic treatment (such as respiratory, urinary tract and otitis media infections) were enrolled. Patients were to be without symptoms of diarrhea during treatment of primary disease with normal stool at time of admission to hospital and <=3 days of antibiotic use prior to hospital admission.
Exclusion criteria
Exclusion criteria: Children with any following conditions were excluded: diarrhea prior to admission, severe immunodeficiency; infusion via central venous catheter (CVC); use of antifungal agents during inpatient treatment and previously known allergy to Saccharomyces boulardii.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the presence of diarrhea;the frequency of diarrhea; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse reactions/events; | — |
Countries
China
Contacts
Public ContactWan Chaomin
Outcome results
None listed