Rheumatoid Arthritis
Conditions
Interventions
1:HuaYuTongBiFang
2:HuaYuTongBiFang+MTX
3:ZhengQingFengTongNing Pills+MTX
4:Methotrexate
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patient must be between 18 and 65 years of age; 2. The patient must meet 2010 American College of Rheumatology /The European League Against Rheumatism classification criteria for the diagnosis of active rheumatoid arthritis and Traditional Chinese Medicine for the diagnosis of "Wang Bi"; 3. Patient has discontinued all disallowed concomitant medications foe the required time prior to the first dose of study drug; 4. Patient has signed the informed consent; 5. The patients must meet Class I-III of the Xray development in RA.
Exclusion criteria
Exclusion criteria: 1. Infection, pregnancy, lactating, traumatic or other stress state; 2. Severe, progressive or uncontrolled cardiac, hepatic, renal, mental disease; 3. Severe hematologic disease including leukemia, aplastic anemia, myelodysplastic syndrome and so on; 4. Be allergic to the medicine we use in the research; 5. Use antibiotics within 1 month; 6. Patients in the Class? of RA; 7. History of other rheumatic autoimmune disease; 8. Patients with active gastrointestinal disease or pitents with peptic ulcer 4 or less weekly; 9. Patients who have previously participated in any clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ACR20/50/70;DAS28 ESR/CRP;TCM sympotoms rating scale;Metagenomic Linkage Group analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAQ-DI;CDAI;SDAI;Sharp's ??;TCM constitution score; | — |
Countries
China
Contacts
Public ContactJun Wang
Outcome results
None listed