malnutrioned patients with malignant tumor of the gastrointestinal tract during the chemotherapy or radiotherapy
Conditions
Interventions
experimental group:Individual nutritional support
control group:General nutrition support
Sponsors
West China Hospital Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age years 18-80;gastric adenocarcinoma and adenocarcinoma of esophagogastric junction patients with pathological staging >=3 after R0 radical correction(The seventh edition of AJCC staging III, II period gastric adenocarcinoma patients),agreeing to accept adjuvent chemotherapy or radiotherapy;colorectal adenocarcinoma patients with pathological staging >=3 after R0 radical correction(The seventh edition of AJCC staging III, II period colorectal adenocarcinoma patients), agreeing to accept adjuvent chemotherapy or radiotherapy; patients with unresectable advanced gastric cancer,agreeing to accept adjuvent chemotherapy or radiotherapy;atients with unresectable advanced colorectal cancer, agreeing to accept adjuvent chemotherapy or radiotherapy; ECOG score 0-2; PG-SGA score >=4; Laboratory test results two weeks before in the group should meet the following requirements: GRA >=1.0*10^9/L or PLT/BPC >=100*10^9/L, TB =30 mL/min, coagulative function is normal; electrocardiogram is normal; expected survival >=6 months; signing the informed conse.
Exclusion criteria
Exclusion criteria: Patients with gastrointestinal dysfunction, intestinal obstruction, pyloric obstruction;patients with acute gastrointestinal hemorrhage; patients being allergic to animal protein or intravenous nutrition;patients with any severe case or uncontrolled systemic disease (e.g: unstable or decompensational aspiratory, cardiac, hepatic, renal diseases, infectious diseases, uncontrolled hypertension, severe arrhythmia, uncontrolled diabetes, active hemorrhage; patients with cardiac pacemaker; patients taking oral drugs to strengthen muscles; women with pregnancy or under lactation, women without contraception or with positive pregnancy test before treatment; patients having history of malignant tumor in 5 years, excepted well-treated basal cell carcinoma, cutaneous squamous cell carcinoma and cancer in situ.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight change rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| QOL;BMI;os;PFS;DFS;PG-SGA scores;AE;BCM; | — |
Countries
China
Contacts
Public ContactLi Qiu
Outcome results
None listed