angina pectoris of coronary heart disease
Conditions
Interventions
four:drug intervention
Sponsors
Xiyuan Hospital, CACMS
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: aged btween 18 to 50 years, half male andfemale, not exceeding 10 years within the same batch; BMI between 19 to 25, mens weight>50kg, womens weight>45kg, similar body weight within the same batch; no positive signs of physical examination; no clinically abnormity of laboratory inspection andECG test;informed consent andvolunteered to participate the trial.
Exclusion criteria
Exclusion criteria: substance abuser, heavy smoker, alcoholist; subjects who had all sorts of drugs, health care products (including traditional Chinese medicine, homemade wine, etc.) two weeks ago;subjects who participated in clinical trials in recent 4 weeks;subjects who had medication with known organ lesions within 3 months or in current drug use;subjects who donated blood or received blood sampling in clinical trial within 3 months; subjects who had severe disease (including critical illness, infectious disease, food anddrug allergy); subjects who had drug allergy history or with allergic constitution; subjects who had medical history of heart, liver, kidney, digestive tract or nervous andmental system; subjects with positive infection indices; pregnant, breastfeeding andmenstrual women, or women planning pregnancy within 3 months; subjects with gastrointestinal disease or received gastrointestinal operation which may influence the drug absorption; subjects who had bad compliance by investigators judgement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cmax;????;AUC;T1/2;Ke;Vd;MRT;Cl;coagulation;Glycoprotein IIb/IIIa;eNOS;iNOS;Protein Kinase C;phosphatidylinositol 3-kinase;RAC-alpha serine/threonine-protein kinase; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine examination;routine urine examination;stool routine test;blood biochemical examination;ECG;HCG; | — |
Countries
China
Contacts
Public ContactRui Gao
Outcome results
None listed