Epithelial Ovarian, Fallopian Tube, andPrimary Peritoneal Cancer
Conditions
Interventions
A:Adjuvant Chemotherapy of Three-step Regimens (ACTS)
Sponsors
Dept. gynecologic oncology,fudan university shanghai cancer center
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Female patients 18-70 years of age; 2. ECOG 0-2; 3. Histologically-confirmed epithelial ovarian or fallopian-tube cancer or primary peritoneal cancer; 4. FIGO2014 stage IIIC/IV; 5. Patients should have received optimal cytoreductive surgery with residual tumor =9 g/dL White blood cell count >=3.0*10^9/L Absolute neutrophil count >=1.5*10^9/L Platelet count >=100 *10^9/L AST (SGOT)/ALT (SGPT) <=2.5 ULN Bilirubin <1.5*ULN Creatinine <1.5*ULN; 8. Ability andwillingness to give written informed consent.
Exclusion criteria
Exclusion criteria: 1. Primary or secondary immune deficiency; 2. Any uncontrolled medical condition that may put the patient at high risk during treatment; 3. Receipt of any other investigational medicinal product within the last 30 days before randomization; 4. Patients with second primary cancer, except: adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, Ductal Carcinoma in Situ (DCIS), stage 1 grade 1 endometrial carcinoma, or other solid tumors including lymphomas (without bone marrow involvement) curatively treated with no evidence of disease for >=5 years; 5. Severe heart/ lung/ liver/ kidney failure; 6. uncontroled or active infection disease; 7. Legal incompetence, limited legal competence, or detainment in an institution for official or legal reasons; 8. Receipt of pelvic or abdominal radiotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;PFS (CA125);safety;quality of life; | — |
Countries
China
Contacts
Public ContactXiaohua Wu
Outcome results
None listed