Senile intertrochanteric fracture
Conditions
Interventions
The tranexamic acid group:A dose of tranexamic acid with15 mg/kg body weight is intravenously administered 15 minutes before incision and a same dose of tranexamic acid is administered 3 hours later.
The control group:100ml of saline is intravenously administered 15 minutes before incision.
Sponsors
Orthopaedical Department of Zhujiang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Senile intertrochanteric fracture receiving internal fixation surgery by proximal femoral nail antirotation; Aged more than 60 years; Preoperative evaluation without surgery anesthesia contraindications.
Exclusion criteria
Exclusion criteria: Presence of deep venous thrombosis revealed by preoperative examination; Contraindication for anticoagulation therapy; Pathological fracture; Suffering myocardial infarction, cerebral infarction or coronary syndrome within the past one year; There are deep vein thrombosis, pulmonary embolism coronary stenting history within the past one year; Duration from injury to operation is more than three weeks; Tranexamic acid allergy; Multiple fractures with the other fracture need surgical treatment; Preoperative hemoglobin<80 g/l.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total perioperative blood loss;Postoperative transfusion rates;Thrombotic events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate within 6 weeks after operation; | — |
Countries
China
Contacts
Public ContactQi Li
Outcome results
None listed