intracranial tumor
Conditions
Interventions
experiment group:Dexmedetomidine
Control:Placebo
Sponsors
Anaesthesiology Department,Peking University First Hospital
Eligibility
Sex/Gender
All
Age
2 Years to 12 Years
Inclusion criteria
Inclusion criteria: (1) Age of 2 years old or more, but not more than 12 years old; (2) Plan to undergo selective craniotomy under general anesthesia for tumor resection; (3) Written informed consent signed by legal guardians.
Exclusion criteria
Exclusion criteria: (1) Refused to participate by the legal guardians; (2) Body weight lower than the 3rd percentile references or higher than 97th percentile references of the body weight developed for aged 2-18 years old; (3) ASA physical classification of IV or higher; (4) Unable to complete preoperative intelligence assessment because of coma, dysnoesia, or language barrier; (5) Diagnosed pulmonary disease (including acuteper respiratory tract infection) or cardiovascular disease (including congenital heart disease, hypertension, hypotension, bradycardia, atrioventricular block, or cardiac insufficiency); (6) Abnormal liver or renal function (liver enzyme or creatinine higher than 1.5 times of theper normal limit; (7) Other congenital diseases that may affect the development of the nervous tem (such as Down Syndrome); (8) Allergy to dexmedetomidine; (9) Other conditions that are considered unsuitable for study participation by the attending pediatricians or investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intelligence quotient; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to emergence;Time to extubation;Consumption of general anesthetics;Depth score of sedation;Emergence agitation;intraoperative adverse events;Length of stay in hospital after surgery;all-cause mortality; | — |
Countries
China
Contacts
Public ContactWang Dongxin
Outcome results
None listed