esophageal carcinoma
Conditions
Interventions
treatment:radiotherapy
treatment:Chemotherapy
treatment:nimotuzumab
Sponsors
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Volunteered to participate signed a written informed consent; Aged 18~70 years old; Both male female; Esophageal squamous cell carcinoma (ESCC) confirmed by histology, unresectable advanced ESCC patients,never received chemotherapy; Have at least one measurable lesion that can be measured (base on RECIST 1.1 )Imaging diagnosis within 15 days before day 0; Expected lifetime>=3month; ECOG performance is 0~1; Hematological examination (=1g/L; WBC>=4.0*10^9/L, NEUT>=2.0*10^9/L, PLT>=100.0*10^9/L, TBil38 degree C; Normalelectrocardiogram/cardiac function; According the protocolto follow-up for observation of efficacy fety; Treatment compliance; Without bad hobby such as drug abuser; Effective contraceptive measures should be taken during crop growth period.
Exclusion criteria
Exclusion criteria: Previously received chemotherapy; Allergyic to drugs in the protocol; Multiple metastatic organs such as liver lung; Complicated with other malignant cancers except cured skin bal cell carcinoma cervical carcinoma in situ; Complicated with other important viscera disease including serious heart disease; Complicated with chronic diarrhea renal insufficiency; Neurological or psychological disorders affecting cognitive abilities, including CNS metastasis; Pregnant or lactating women(pre-menopaul women should check urine pregnancy experiment before entry).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR;fety; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to Progression;Progression free survival;overall survival; | — |
Countries
China
Contacts
Public ContactSUN XIAONAN
Outcome results
None listed