bronchiectasis
Conditions
Interventions
A:atomization inhalation treatment for three month, then oral expectorant drugs for three month
B:oral expectorant drugs for three month then atomization inhalation treatment for three month
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with bronchiectasis, and given priority to bronchiectasis performance,conforms to the diagnosis of bronchiectasis (BE) standard: repeatedly cough, cough with sputum(or) history of hemoptysis. By the high resolution CT diagnosis of bronchiectasis:the airway diameter larger than with pulmonary artery diameter; Bronchial not tapering more than 2 cm; Pleural wall visible bronchial as 1 cm; 2. In bronchiectasis stable period, ranging in age from 18 to 80 years old; No smoking or quit smoking > more than 1 year, sputum volume is more than 10 ml 24 hours a day; 3. Bronchiectasis stable period is defined as: (1) the 24 hours of sputum volume change < 20%; (2) The change of the FEV1 and FVC < 20%; (3) no obvious change in respiratory symptoms; (4) the type and dosage of the drug use without obvious change;The above symptoms last more than three weeks can be diagnosed as Bronchiectasis stable period. 4. The participants agreed to participate in this study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. With refractory bronchial asthma, active tuberculosis, heart failure, idiopathic pulmonary fibrosis, cystic fibrosis bronchiectasis, pulmonary embolism, disease history and other effects observed indicators; 2. A history of allergic disease; 3. A history of acute and chronic cardiopulmonary kidney tumors; 4. Hard to cooperate with or understand ability is limited, can't cooperate with researchers; 5. The expectorant drug allergies; 6. Patients with pregnancy and lactation; 7. Can't timely follow-up of patients; 8. Rounding out the first 4 weeks had oral/intravenous antibiotics (except Macrolide antibiotics).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sputum volume 24 hours a day;The color of sputum;Leicester Cough Questionnaire(LCQ);induced Sputum cell count; | — |
Secondary
| Measure | Time frame |
|---|---|
| lung function;Sputum viscosity;6 minute walking test;differential cell counts in induced sputum; | — |
Countries
China
Contacts
Public ContactZE GUANG ZHENG
Outcome results
None listed