Acute ischemic stroke
Conditions
Interventions
low-statin:atorvastatin 10mg
large-statin:atorvastatin 80mg
Sponsors
Department of neurology of Hospital of Shenyang military area command of Chinese PLA
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The patients with clear consciousness should sign informed consent,or the legal representative of the patients should sign informed consent; 2. The patients should be diagnosed as acute ischemic stroke within 48 hours of onset.Diagnostic criteria should meet the diagnosis standard revised in the Fourth National Academic Conference on cerebrovascular disease; 3. The age of the patients regardless of gender should be between 18-80; 4. Neurological deficits include NIHSS scores of 6-20; 5. There is no bleeding in brain CT; 6. The patients should have the first stroke attack,or the patients should have the second stroke attack with no sequel of the first stroke attack, or the patients should have the second stroke attack with clear NIHSS scores.
Exclusion criteria
Exclusion criteria: 1. Patients with liver diseases (glutamic pyruciv transaminase or aspartate aminotransferase is higher than the normal value of 1~1.5 times), kidney diseases (urea or creatinine is greater than the normal range above 10%), increase in muscle enzymogram above 10%; 2. Patients having a history of allergy to this class of drugs; 3. Patients who participated in other clinical trials within 3 months; 4. Patients previously taking statins in 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NIHSS scores;mRS;Baethel Index;Stroke recurrence;cardiovascular event; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMA;HRSD;MMSE;MoCA;BAI and PWV;color Doppler ultrasonography; | — |
Countries
China
Contacts
Public ContactChen Huisheng
Outcome results
None listed