hepatitis B-related hepatocellular carcinoma
Conditions
Interventions
Sponsors
Eastern Hepatobiliary Surgical hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. age 18 to 70 years; 2. positive test for Hepatitis B surface antigen (HBsAg) and negative test for antibody to hepatitis C virus (HCV-Ab) or human immunodeficiency virus; 3. serum hepatitis B virus-deoxyribonucleic acid (HBV-DNA) level lower than 2000 IU/ml; 4. Barcelona Clinic Liver Cancer (BCLA) stage 0, A or a solitary tumor with diameter> 5cm; 5. no extrahepatic metastasis; 6. no radiologic evidence of invasion into major portal/hepatic venous branches; 7. good liver function with Child - Pugh Class A and baseline serum alanine aminotransferase (ALT) level< 2 times the upper limit of normal (reference range<40 IU/L), with no history of encephalopathy, ascites refractory to diuretics, esophago-gastric variceal bleeding; 8. good renal function(a serum creatinine level < 133 umol/L); 9. no previous treatment for hepatitis B with nucleoside or nucleotide analogues or both; 10. no treatment with interferon or other immunomodulators within the previous 12 months; 11. a serum amylase or lipase level lower than 1.5 times the upper limit of normal; 12. no previous treatment of HCC; 13. negative resection margin (R0 resection); 14. histopathological result of the resected specimens being HCC. Eligible patients were excluded if they refused to participate.
Exclusion criteria
Exclusion criteria: patients were excluded if they refused to participate or they are not eligible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of HBV reactivationon;Rate of tumor recurrence;survival rate; | — |
Countries
CHina
Contacts
Public ContactWeiping Zhou
Outcome results
None listed