Primary osteoarthritis of knee
Conditions
Interventions
treatment group:1.0 g of tranexamic acid in 100 mL of saline is administered immediately before making incision
control group:standard fluid management
Sponsors
Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients who plan to undergo primary TKA on simultaneous bilateral knee joint with a diagnosis of osteoarthritis or aseptic bone necrosis, but not of rheumatoid arthritis; 2. All patients have normal preoperative platelet count, normal prothrombin time, normal partial thromboplastin time, and normal international normalized ratio; 3. The use of only balanced electrolyte solutions and/or albumin for plasma volume restitution.
Exclusion criteria
Exclusion criteria: 1. Allergy to tranexamic acid; 2. Receiving warfarin or heparin; had a history of hemophilia, deep venous thrombosis, pulmonary embolism, or renal impairment; or were pregnant; 3. Patients with any cardiovascular problems (such as myocardiac infarction history, atrial fibrillation, angina); 4. Patients with cerebrovascular conditions (such as previous stroke or vascular surgery history); 5. Patients with thromboembolic disorders, or those exhibiting a deteriorating general condition; 6. Preoperative anemia (a hemoglobin value of 1.4, or a prolonged partial thromboplastin time [>1.4 times normal]).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients who were transfused with allogeneic blood;Amounts of allogeneic blood transfused; | — |
Secondary
| Measure | Time frame |
|---|---|
| Amount of drainage;Average amounts of blood loss;Complications (myocardial infarction, stroke, deep vein thrombosis, pulmonary embolism, any thrombosis, renal failure): CE + DU (Postoperative Day 5);Active range of motion (pre-operation and post-operative Day 7);Decreased Hb;Post-operative Hb (post-operative Day 1,3,5);Thigh girth (at 1st week after surgery);Calf girth (at 1st week after surgery);KSS score (at 6th week after surgery);VAS (everyday after surgery);Calculated blood loss; | — |
Countries
China
Contacts
Public ContactZhu jinyu
Outcome results
None listed