Retinoblastoma
Conditions
Interventions
venous chemotherapy group:venous chemotherapy
arterial interventional chemotherapy group:arterial interventional chemotherapy
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 99 Years
Inclusion criteria
Inclusion criteria: 1) New onset unilateral retinoblastoma of group D or E without high-risk clinical factors 2) Normal bone marrow function: ANC >=750/uL; Plt >75,000/uL; Hb>=8.0 gm/dL; 3) Normal liver function: total bilirubin =2 g/dL; 4) Normal kidney function: Ccr >=70ml/min/1.73 m2 or normal Scr according to age and gender; 5) Normal coagulation function: INR<1.4; APTT<34s; 6) Volunteer to participate in the clinical trials and sign the informed consent form.Being able to be followed up according to the schedule.
Exclusion criteria
Exclusion criteria: 1)Patients with previous anti-tumor treatment 2)Fundus examination show bilateral retinoblastoma 3)Known medical conditions making participation ill-advised (e.g. congenital heart diseaseacute or chronic infectious disease or other malignancy)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression-free eye salvage rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| progression-free survival rate;objective response rate;overall survival; | — |
Countries
China
Contacts
Public ContactFan Xianjun
Outcome results
None listed