nasopharyngeal carcinoma
Conditions
Interventions
Experimental:cisplatin and 5-FU chemotherapy once a week
Control:Traditional PF chemotherapry once three week
Sponsors
Fujian Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with age 20-70 years old; 2. Patients with histologically confirmed as nasopharyngeal carcinoma; 3. Patients with stage III-IVb according to 7th AJCC staging system, with the life expectancy of more than or equal to 12 months; 4. Patients who are suitable for and tolerate to chemo-radiotherapy; 5. At least one radiographically documented lesion assessable according to RECIST solid tumor criteria by MRI; 6. Patients with ECOG score of 0-1; 7. Haemoglobin >=90g/L, neutrophils >=1.5*10^9/L, platelet count >=100*10^9/L; 8. Hepatic function: ALT and AST< 3*ULN, TBIL<2.0*ULN.
Exclusion criteria
Exclusion criteria: Previous radiotherapy; 4) Currently receive radiotherapy, which is part of treatment protocols after the resection of primary tumor; 5) Clinically significant ongoing infection (Need intravenous antibiotics), including active TB, and/or confirmed HIV infection; 6) Un-controlled diatebes, pulmonary fibrosis, serious lung disease, interstitial pneumonia, heart and liver failure; 7) Un-controlled hypertension (systolic blood pressure >=180 mmHg, and/or diastolic blood pressure >=130 mmHg under the sedentary condition); 8) Pregnant (should be excluded by detection of HCG) or breast-feeding women; 9) History of coronary heart disease and myocardial infarction within 12 months, or presented with high risk factors of un-controlled arrhythmia or cardiac insufficiency; 10) Previously Participate in other drug interventional clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute toxicity reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission Rate;5-year survival rate; | — |
Countries
TAIWAN CHINA
Contacts
Public ContactLin Shaojun
Outcome results
None listed