Glioma
Conditions
Interventions
Group A:Temozolomide capsule -Refference
Group B:Temozolomide capsule -T
Sponsors
Beijing Shijitan Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. The imaging and pathological histology and/or cytology diagnosis of glioblastoma and anaplastic astrocytoma and other participants contains acceptable for mo thiazole amine solution treatment of tumor subjects; 2. Age 18-60 years old (including threshold), gender not limited; 3. KPS score 60 or more points; 4. Expected lifetime is more than 3 months; 5. ANC>1.5*10^9/L, PLT>100*10^9/L, HGB>90g/L; 6. ALT<3ULN, AST <3 ULN, TBIL<1.5 ULN, Cr <1.5 ULN; 7. Sterilization surgery, after menopause or agreed to in the study and research during the period after the end of treatment using an approved within six months of physical contraception birth control (such as a house or a condom), and sign the subjects in clinical trials should be avoided during pregnant notice "(hereinafter referred to as birth control guidelines, appendix 1) female subjects;Sterilization surgery or agreed to in the study and research during the period after the end of treatment using an approved within six months of physical contraception, and sign the subjects in clinical trials should be avoided during pregnant notice" male subjects; 8. Test details before the nature, significance, may benefit, inconvenience and potential risk, understand the research program and voluntary signed informed consent in writing.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation women; 2. The glass type of allergy to alkylating agent; 3. Unable to swallow or always accept the urea nitrate class alkylating agent severe vomiting; 4. Four weeks before the beginning of the experiment cytotoxic drugs chemotherapy; 5. Can't control epilepsy with author; 6. Unable to control high blood pressure, high blood sugar; 7. Have obvious intestinal obstruction, gastrointestinal bleeding, or present diarrhea; 8. Has a history of chronic bowel disease, stomach or intestinal resection; 9. Can't cooperation, can't communicate with the normal person; 10. Participated in other clinical subjects within 30 days; 11. 2 months prior to test blood or blood donation amount more than 200 ml; N ot suitable for participants'.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulse;Respiration;Blood Pressure;Temperature;ECG; | — |
Countries
China
Contacts
Public ContactXinghe Wang
Outcome results
None listed