Impact of two anesthesia maintenance methods on incidence of early delirium and duration of long-term survival in elderly patients after surgery for malignant tumor: a randomized controlled trial

Conditions

Malignant tumor

Cao SJ, Zhang Y, Zhang YX, Zhao W, Pan LH, Sun XD, Jia Z, Ouyang W, Ye QS, Zhang FX, Guo YQ, Ai YQ, Zhao BJ, Yu JB, Liu ZH, Yin N, Li XY, Ma JH, Li HJ, Wang MR, Sessler DI, Ma D, Wang DX, First Study of Perioperative Organ Protection (SPOP1) investigators.

2023-06-0457 citations

10.1016/j.bja.2023.04.024

Long-term survival in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: follow-up of a multicentre randomised trial

Shuang-Jie Cao, Yue Zhang, Yuxiu Zhang, Wei Zhao, Linghui Pan et al. (23 authors)

British Journal of Anaesthesia2023-06-0338 citations

10.1016/j.bja.2023.01.023

Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults

Yuehua Zhang, Guojin Shan, Y.-X. Zhang, Shaowei Cao, S N Zhu et al. (8 authors)

British Journal of Anaesthesia2018-07-27168 citations

10.1016/j.bja.2018.05.059

Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial

Yue Zhang, Huijuan Li, Dong‐Xin Wang, Huiqun Jia, Xude Sun et al. (20 authors)

BMJ Open2017-11-0120 citations

10.1136/bmjopen-2017-018607

Interventions

Sevoflurane group:Anesthesia is maintained with inhalation of sevoflurane

Propofol group:Anesthesia is maintained with intravenous infusion of propofol

Eligibility

Sex/Gender

All

Age

65 Years to 90 Years

Inclusion criteria

Inclusion criteria: Participants must meet all of the following criteria: 1. Aged >= 65 years and < 90 years; 2. Scheduled to undergo surgery for cancer, with an expected duration of 2 hours or more, under general anesthesia; 3. Diagnosed as primary cancer, do not receive radio- or chemotherapy before surgery; 4. Agree to participate, and give signed written informed consents.

Exclusion criteria

Exclusion criteria: Patients will be excluded if they meet any of the following criteria: 1. Refuse to participate in the study; 2. Previous history of schizophrenia, epilepsy, Parkinsonism, or myasthenia gravis; 3. Inability to communicate in the preoperative period because of coma, profound dementia, language barrier, or end-stage disease; 4. Critical illness (preoperative American Society of Anesthesiologists physical status classification >= IV), severe hepatic dysfunction (Child-Pugh class C), or severe renal dysfunction (undergoing dialysis before surgery); 5. Neurosurgery; 6. Other reasons that are considered unsuitable for study participation by the responsible surgeons or investigators (reasons must be recorded in the case report form).

Design outcomes

Primary

Measure	Time frame
The incidence of delirium during the first 7 days after surgery;Duration of overall survival after surgery;	—

Secondary

Measure	Time frame
Incidence of postoperative complications within 30 days after surgery;Recurrence-free survival after surgery;Cognitive function at 30 days after surgery;Event-free survival after surgery;The percentage of intensive care unit (ICU) admission after surgery;The proportion of ICU admission with endotracheal intubation after surgery;The length of stay in ICU after surgery;The length of stay in hospital after surgery;	—

Measure

Time frame

Incidence of postoperative complications within 30 days after surgery;Recurrence-free survival after surgery;Cognitive function at 30 days after surgery;Event-free survival after surgery;The percentage of intensive care unit (ICU) admission after surgery;The proportion of ICU admission with endotracheal intubation after surgery;The length of stay in ICU after surgery;The length of stay in hospital after surgery;

—

Countries

China

Contacts

Public ContactWang DongXin

Peking University First Hospital

wangdongxin@hotmail.com+86 13910731903

Outcome results

None listed