Effect and security of different dosages of dexmedetomidine on sciatic nerve block in elderly patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-15006078

Enrollment

Unknown

Registered

2015-03-06

Start date

2015-04-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

great saphenouse varicose

Interventions

Group R:ultrasound guided sciatic nerve block with lidocaine and ropivacaine combined with saline

Group RD1:ultrasound guided sciatic nerve block with lidocaine and ropivacaine combined with 25ug dexmedetomidine

Group RD2:ultrasound guided sciatic nerve block with lidocaine and ropivacaine combined with 50ug dexmedetomidine

Group RD3:ultrasound guided sciatic nerve block with lidocaine and ropivacaine combined with 75ug dexmedetomidine

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: Scheduled for the elderly patients who undergone elective unilateral great saphenouse vein surgery, older than 65years, ASA I-III.

Exclusion criteria

Exclusion criteria: 1. allergy or hypersensitivity to local anesthetics; 2. infection at the intended injection site; 3. peripheral neuropathy; 4. language barrier; 5. disturbance of consciousness.

Design outcomes

Primary

Measure	Time frame
the sensory onset and duration time of sural nerve;the sensory onset and duration time of lateral sural cutaneous nerve;the sensory onset and duration time of superificial peroneal nerve;the sensory onset and duration time of deep peroneal nerve;the sensory onset and duration time of lateral plantar nerve;the sensory onset and duration time of medial plantar nerve;the motor onset and duration time of common peroneal nerve;the motor onset and duration time of tibial nerve;the basic mean arterial pressure before nerve blockade;the mean arterial pressure after nerve blockade 10mins;the mean arterial pressure after nerve blockade 30mins;the mean arterial pressure after nerve blockade 60mins;the mean arterial pressure after nerve blockade 120mins;the basic heart rate before nerve blockade;the heart rate after nerve blockade 10mins;the heart rate after neve blockade 30mins;the heart rate after nerve blockade 60mins;the heart rate after nerve blockade 120mins;the basic SPO2 before nerve blockade;the SPO2 after nerve blockade 10mins;the SPO2 after nerve blockade 30mins;the SPO2 after nerve blockade 60mins;the SPO2 after nerve blockade 120mins;the OAA/S score before nerve blockade;the OAA/S score after nerve blockade 10mins;the OAA/S score after nerve blockade 30mins;the OAA/S score after nerve blockade 60mins;the OAA/S score after nerve blockade 120mins;	—

Measure

Time frame

the sensory onset and duration time of sural nerve;the sensory onset and duration time of lateral sural cutaneous nerve;the sensory onset and duration time of superificial peroneal nerve;the sensory onset and duration time of deep peroneal nerve;the sensory onset and duration time of lateral plantar nerve;the sensory onset and duration time of medial plantar nerve;the motor onset and duration time of common peroneal nerve;the motor onset and duration time of tibial nerve;the basic mean arterial pressure before nerve blockade;the mean arterial pressure after nerve blockade 10mins;the mean arterial pressure after nerve blockade 30mins;the mean arterial pressure after nerve blockade 60mins;the mean arterial pressure after nerve blockade 120mins;the basic heart rate before nerve blockade;the heart rate after nerve blockade 10mins;the heart rate after neve blockade 30mins;the heart rate after nerve blockade 60mins;the heart rate after nerve blockade 120mins;the basic SPO2 before nerve blockade;the SPO2 after nerve blockade 10mins;the SPO2 after nerve blockade 30mins;the SPO2 after nerve blockade 60mins;the SPO2 after nerve blockade 120mins;the OAA/S score before nerve blockade;the OAA/S score after nerve blockade 10mins;the OAA/S score after nerve blockade 30mins;the OAA/S score after nerve blockade 60mins;the OAA/S score after nerve blockade 120mins;

—

Secondary

Measure	Time frame
anesthesia efficacy in operation;	—

Countries

China

Contacts

Public ContactXuzhong Xu

xuzhong@263.net+86 13706657799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026