Achalasia
Conditions
Interventions
A:Liu-POEM
B:conventional POEM
Sponsors
the second affiliated hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients aged between 18 and 80 years, body mass index less than 40kg/?; The diagnosis of achalasia was based on clinical symptoms(Eckardt score>3): dysphagia,regurgitation, chest pain, weight loss; Barium esophagogram demonstrating consecutive dilatation of the esophageal body, typical 'bird's peak' appearance of the LES with decrease in emptying times; Patients with no severe achalasia (X-ray showed expansion and s-shaped tortuosity of the lower esophagus).
Exclusion criteria
Exclusion criteria: (1) Patients refused to sign the informed consent; (2) inability to tolerate general anesthesia; (3) Pregnant women or lactating women; (4) Long-time use of hormone therapy or anticoagulant therapy; (5) Patients with a life expectancy less than 6 month; (6) severe pulmonary disease and renal insufficiency (Blood creatinine >200 umol/L); (7)severe achalasia (X-ray showed expansion and s-shaped tortuosity of the lower esophagus); (8) cirrhosis with portal hypertension; (9) patients have concomitant esophageal or upper gastric tumors; (10) Patient who has took part in other studies that can affect results of the present study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| operation time;Symptom remission rate (Eckardt score);complications and recurrence in short-term follow-up (6months); | — |
Secondary
| Measure | Time frame |
|---|---|
| frequency of regular hemostasis;submucosal tissuhealing time;eduration of postoperative pain;Esophageal X-ray angiography (shape and width of esophagus);Pain medication requirements;tissue injury (assessed by MRI);length of hospital stay;hospitalization expenses; | — |
Countries
China
Contacts
Public ContactLiu Binrong
Outcome results
None listed