Patients undergoing elective resection of stomach, small intestine and colon, who has indications for parenteral nutrition (PN) after operation.
Conditions
Interventions
experimental group:10% Compound Amino Acid(19) and Alanyl Glutamine Injection
control group:8.5% Compound Amino Acid Injection(18AA-II)
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years, weight 45-75kg; 2. Patients undergoing elective resection of stomach, small intestine and colon (including laparoscopic surgery), who has indications for parenteral nutrition (PN) after operation; 3. Nutritional risk screening (NRS 2002) grade equal and greater than 3; 4. Hb more than at least 80g/L, ALT, TBIL and DBIL levels are less than 1.5 times of the upper limit of normal. Serum creatinine is normal; 5. Patients without long-term fever, thyroid function hyperfunction, hypothyroidism or metabolic diseases such as diabetes, infectious diseases, mental illness; 6. Without radiation and chemotherapy therapy 3 weeks before operation; 7. Without PN 3 weeks before operation; 8. Understand and voluntarily endorse informed consent.
Exclusion criteria
Exclusion criteria: Subjects complying with any of the following exclusion criteria are not eligible to participate in this study: 1. The intraoperative bleeding >1000 ml, or intraoperative or postoperative supplementation of blood and/or blood products; 2. Serious organ damage, such as CHF (congestive heart-failure), patients with clinical symptoms of coronary artery disease and arrhythmia uncontrollable by existing medicines, etc.; 3. Past history of severe cerebrovascular disease; 4. Congenital abnormalities of amino acid metabolism or allergic to amino acids, fat emulsion, soybean etc.; 5. Participate in other clinical research at the same time; 6. Electrolyte imbalance before using experimental drug; 7. The patients that researchers do not consider fit for the trial; 8. Pregnancy or breast-feeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glutamine;Prealbumin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum free amino acid profile;The ratio of lactulose to mannitol in urine(L/M ratio); | — |
Countries
China
Contacts
Public ContactJianchun Yu
Outcome results
None listed