Advanced gastrointestinal malignant ascites
Conditions
Interventions
Experimental:Cinobufacini intraperitoneal injection
Control:5 -fluorouracil intraperitoneal injection
Sponsors
Dongfang Hospital, Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) In line with advanced gastrointestinal diagnostic criteria for malignant ascites; (2) Age 18-80 years old; (3) 2 weeks is not systemic chemotherapy, peritoneal perfusion therapy; (4) 2 weeks of unused cinobufotalin preparations; (5) ECOG performance status score 0-3 points; (6) In determining the amount of ascites above grade level II peritoneal effusion, ascites amount 1000-3000ml; (7) Volunteered to participate and signed informed consent.
Exclusion criteria
Exclusion criteria: Patient compliance with any one of the following exclusion criteria are not enrolled in trials: (1) ascites non-neoplastic causes of cirrhosis of the liver, peritonitis, and hypoalbuminemia; (2) for toad allergies or adverse reactions arrhythmia; (3) B ultrasound or CT scan confirmed the peritoneal cavity to separate the impact of ascites and ascites estimates; (4) cardiac function III-IV grade; (5) ALT> 3 times the upper limit of normal and / or TBIL >2 upper limit of normal; (6) renal function is 3 and 3 above; (7) of the II degree and II than neutropenia, and / or moderate and moderate to severe anemia, and / or of the degree of thrombocytopenia II and II above; (8) The combined mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal malignant ascites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vascular endothelial growth factor;RBC ascites;Ascites tumor markers in the digestive tract;ECOG performance status;After the infusion of drug ascites drainage time , the number of drainage and drainage; | — |
Countries
China
Contacts
Public ContactKaiwen Hu
Outcome results
None listed